• ZECID OMEPRAZOLE 20mg 200ct (Prilosec, Zegerid)

DRUG CLASS AND MECHANISM: Omeprazole is in a class of drugs called proton pump inhibitors (PPI) that block the production of acid by the stomach. Other drugs in the class include lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), and esomeprazole (Nexium). Proton pump inhibitors are used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD) and the Zollinger-Ellison syndrome, which are all caused by stomach acid. Omeprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal. Zegerid contains omeprazole and an antacid (sodium bicarbonate). The FDA approved omeprazole in September 1989.

 

PRESCRIBED FOR: Omeprazole is used for treating acid-induced inflammation and ulcers of the stomach and duodenum; gastroesophageal reflux disease (GERD); erosive esophagitis, heartburn; prevention of upper gastrointestinal bleeding in critically ill patients; and Zollinger-Ellison Syndrome. It also is used in combination with antibiotics for eradicating H. pylori infection of the stomach.

DOSING

For ulcers, GERD, erosive esophagitis and eradication of H. pylori, the recommended dose for adults is 20-40 mg daily. Ulcer healing usually occurs within 4-8 weeks.

The usual dose for the prevention of upper gastrointestinal bleeding in critically ill patients is 40 mg daily for 14 days.

Zecid OTC is used for treating heartburn for up to two weeks, and the usual dose is 20 mg daily.

Warnings / Precautions

Exclude malignancy, prolonged use, hepatic impairment. Pregnancy, lactation, children <1 yr. Elderly and Asians (increased bioavailability).

Adverse Reactions

Diarrhoea, nausea, fatigue, constipation, vomiting, flatulence, acid regurgitation, taste perversion, arthralgia, myalgia, urticaria, dry mouth, dizziness, headache, paraesthesia, abdominal pain, skin rashes, weakness, back pain, upper respiratory infection, cough.

Potentially Fatal: Anaphylaxis.

Overdose Reactions

Confusion, drowsiness, blurred vision, tachycardia, nausea, flushing, diaphoresis, headache, and dry mouth. Treatment is supportive; not dialysable.

Mechanism of Actions

Omeprazole suppresses gastric acid secretion by specific inhibition of the enzyme system hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase) present on the secretory surface of the gastric parietal cell.

Onset: Antisecretory: approx 1 hr; peak effect:0.5-3.5 hr.

Duration: 72 hr.

Absorption: Rapid but variable (oral); dose-dependent. Bioavailability: Oral: approx 30-40%.

Distribution: Protein-binding: 95%.

Metabolism: Extensively hepatic; converted to hydroxyomeprazole and omeprazole sulfone.

Excretion: Via urine (77%) and bile. Elimination half-life: 0.5-3 hr.

Storage

Intravenous: Store at 15-30 °C. Protect from light. Oral: Store at 15-30 °C. Protect from light.

 

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ZECID OMEPRAZOLE 20mg 200ct (Prilosec, Zegerid)

  • Product Code: ZECID OMEPRAZOLE 20mg
  • Availability: In Stock
  • $19.99
  • $15.88

  • Ex Tax: $15.88